„lead discovery“
Suchergebnisse
1.000+ Treffer
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A solving method based on neural network for a class of multi-leader–follower games
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Gene expression profiling leads to discovery of correlation of matrix metalloproteinase 11 and heparanase 2 in breast cancer progression
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Screening North American plant extracts in vitro against Trypanosoma brucei for discovery of new antitrypanosomal drug leads
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Leader-following consensus of nonlinear multi-agent systems with switching topologies and unreliable communications
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Cover Picture: Integration of Multiple Analytical and Computational Tools for the Discovery of High‐Potency Enzyme Inhibitors from Herbal Medicines (ChemMedChem 23/2016)
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Cover Picture: Structural Simplification of Bedaquiline: the Discovery of 3‐(4‐(N, N ‐Dimethylaminomethyl) phenyl) quinoline‐Derived Antitubercular Lead Compounds (ChemMedChem 2/2017)
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Structural Differentiation in Social Media – Adhocracy, Entropy, and the "1 % Effect"
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Frontispiece: Synthesis of Highly Substituted 1,2‐Diazetidin‐3‐ones, Small‐Ring Scaffolds for Drug Discovery
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Front Cover: Combined Scaffold Evaluation and Systems‐Level Transcriptome‐Based Analysis for Accelerated Lead Optimization Reveals Ribosomal Targeting Spirooxindole Cyclopropanes (ChemMedChem 18/2019)
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Inside Cover: Improved 2,4‐Diarylthiazole‐Based Antiprion Agents: Switching the Sense of the Amide Group at C5 Leads to an Increase in Potency (ChemMedChem 9/2010)
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Inside Cover: Inhibition of Eimeria tenella CDK‐Related Kinase 2: From Target Identification to Lead Compounds (ChemMedChem 8/2010)
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Cover Picture: Consistent Cell‐selective Analog Series as Constellation Luminaries in Chemical Space (Mol. Inf. 12/2020)
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Back Cover: From On‐Target to Off‐Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti‐ Trypanosoma brucei Drug Discovery Lead Molecules (ChemMedChem 7/2013)
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Cover Feature: Activity‐Directed Synthesis of Inhibitors of the p53/h DM2 Protein–Protein Interaction (Chem. Eur. J. 47/2020)
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Inside Cover: Seamless Integration of Dose‐Response Screening and Flow Chemistry: Efficient Generation of Structure–Activity Relationship Data of β‐Secretase (BACE1) Inhibitors (Angew. Chem. Int. Ed. 6/2014)
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Molecular Lead Clusters—From Unexpected Discovery to Rational Synthesis
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The Discovery of CCR5 Receptor Antagonists for the Treatment of HIV Infection: Hit‐to‐Lead Studies
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On the Art of Compiling and Using 'Drug‐Like' Chemical Fragment Spaces
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Synthesis of Diverse Lactam Carboxamides Leading to the Discovery of a New Transcription‐Factor Inhibitor †
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Synthesis of Diverse Lactam Carboxamides Leading to the Discovery of a New Transcription‐Factor Inhibitor †