„bioisostere“

Suchergebnisse

1.000+ Treffer

• Negative allosteric modulators of NMDA receptors with GluN2B subunit: Alanine‐derived benzoxazolone bioisosteres of 2‐methyl‐3‐benzazepine‐1,7‐diols
  Markus, Alexander ; Frehland, Bastian ; Schepmann, Dirk ; Wünsch, Bernhard
• Frontispiece: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere
  Chalmers, Benjamin A. ; Xing, Hui ; Houston, Sevan ; Clark, Charlotte ; Ghassabian, Sussan ; Kuo, Andy ; Cao, Benjamin ; Reitsma, Andrea ; Murray, Cody‐Ellen P. ; Stok, Jeanette E. ; Boyle, Glen M. ; Pierce, Carly J. ; Littler, Stuart W. ; Winkler, David A. ; Bernhardt, Paul V. ; Pasay, Cielo ; De Voss, James J. ; McCarthy, James ; Parsons, Peter G. ; Walter, Gimme H. ; Smith, Maree T. ; Cooper, Helen M. ; Nilsson, Susan K. ; Tsanaktsidis, John ; Savage, G. Paul ; Williams, Craig M.
• Frontispiz: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere
  Chalmers, Benjamin A. ; Xing, Hui ; Houston, Sevan ; Clark, Charlotte ; Ghassabian, Sussan ; Kuo, Andy ; Cao, Benjamin ; Reitsma, Andrea ; Murray, Cody‐Ellen P. ; Stok, Jeanette E. ; Boyle, Glen M. ; Pierce, Carly J. ; Littler, Stuart W. ; Winkler, David A. ; Bernhardt, Paul V. ; Pasay, Cielo ; De Voss, James J. ; McCarthy, James ; Parsons, Peter G. ; Walter, Gimme H. ; Smith, Maree T. ; Cooper, Helen M. ; Nilsson, Susan K. ; Tsanaktsidis, John ; Savage, G. Paul ; Williams, Craig M.
• Front Cover: Discovery of Benzo (d) imidazole‐6‐sulfonamides as Bromodomain and Extra‐Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain (ChemMedChem 20/2022)
  Cipriano, Alessandra ; Milite, Ciro ; Feoli, Alessandra ; Viviano, Monica ; Pepe, Giacomo ; Campiglia, Pietro ; Sarno, Giuliana ; Picaud, Sarah ; Imaide, Satomi ; Makukhin, Nikolai ; Filippakopoulos, Panagis ; Ciulli, Alessio ; Castellano, Sabrina ; Sbardella, Gianluca
• Front Cover: Optimization of Pyrazoles as Phenol Surrogates to Yield Potent Inhibitors of Macrophage Migration Inhibitory Factor (ChemMedChem 11/2018)
  Trivedi‐Parmar, Vinay ; Robertson, Michael J. ; Cisneros, José A. ; Krimmer, Stefan G. ; Jorgensen, William L.
• Front Cover: Photoredox‐Catalyzed Decarboxylative Oxidation of Arylacetic Acids (Chem. Asian J. 17/2018)
  Sakakibara, Yota ; Cooper, Phillippa ; Murakami, Kei ; Itami, Kenichiro
• Cover Feature: Not Your Usual Bioisostere: Solid State Study of 3D Interactions in Cubanes (Chem. Eur. J. 28/2019)
  Flanagan, Keith J. ; Bernhard, Stefan S. R. ; Plunkett, Shane ; Senge, Mathias O.
• Front Cover: Sulfonimidamides and Imidosulfuric Diamides: Compounds from an Underexplored Part of Biologically Relevant Chemical Space (Chem. Eur. J. 28/2019)
  Zasukha, Sergiy V. ; Timoshenko, Vadim M. ; Tolmachev, Andrey A. ; Pivnytska, Valentyna O. ; Gavrylenko, Oleksii ; Zhersh, Serhii ; Shermolovich, Yuriy ; Grygorenko, Oleksandr
• Cover Feature: (2R, 3S)‐3,4,4,4‐Tetrafluorovaline: A Fluorinated Bioisostere of Isoleucine (Eur. J. Org. Chem. 13/2020)
  Brewitz, Lennart ; Noda, Hidetoshi ; Kumagai, Naoya ; Shibasaki, Masakatsu
• Structural Consequences of the 1,2,3‐Triazole as an Amide Bioisostere in Analogues of the Cystic Fibrosis Drugs VX‐809 and VX‐770
  Doiron, Jake E. ; Le, Christina A. ; Bacsa, John ; Breton, Gary W. ; Martin, Kenneth L. ; Aller, Stephen G. ; Turlington, Mark
• Inside Cover: Water‐Soluble Non‐Classical Benzene Mimetics (Angew. Chem. Int. Ed. 18/2020)
  Levterov, Vadym V. ; Panasyuk, Yaroslav ; Pivnytska, Valentyna O. ; Mykhailiuk, Pavel K.
• Cover Feature: Cubane Electrochemistry: Direct Conversion of Cubane Carboxylic Acids to Alkoxy Cubanes Using the Hofer–Moest Reaction under Flow Conditions (Chem. Eur. J. 2/2020)
  Collin, Diego E. ; Folgueiras‐Amador, Ana A. ; Pletcher, Derek ; Light, Mark E. ; Linclau, Bruno ; Brown, Richard C. D.
• Innentitelbild: Water‐Soluble Non‐Classical Benzene Mimetics (Angew. Chem. 18/2020)
  Levterov, Vadym V. ; Panasyuk, Yaroslav ; Pivnytska, Valentyna O. ; Mykhailiuk, Pavel K.
• Strain‐Release‐Driven Modular Synthesis of Oxetane‐Based Amide Bioisosteres: Concise, Robust and Scalable Approach
  Spránitz, Péter ; Sőregi, Petra ; Hegedüs, Kristóf ; Igriczi, Barbara ; Szakács, Gergely ; Jemnitz, Katalin ; Szabó, Pál ; Galushchak, Yarema ; Mykhailiuk, Pavel K. ; Soós, Tibor
• Strain‐Release‐Driven Modular Synthesis of Oxetane‐Based Amide Bioisosteres: Concise, Robust and Scalable Approach
  Spránitz, Péter ; Sőregi, Petra ; Hegedüs, Kristóf ; Igriczi, Barbara ; Szakács, Gergely ; Jemnitz, Katalin ; Szabó, Pál ; Galushchak, Yarema ; Mykhailiuk, Pavel K. ; Soós, Tibor
• Eu (OTf) 3 ‐Catalyzed Formal Dipolar (4π+2σ) Cycloaddition of Bicyclo‐(1.1.0) butanes with Nitrones: Access to Polysubstituted 2‐Oxa‐3‐azabicyclo (3.1.1) heptanes
  Zhang, Jian ; Su, Jia‐Yi ; Zheng, Hanliang ; Li, Hao ; Deng, Wei‐Ping
• Eu (OTf) 3 ‐Catalyzed Formal Dipolar (4π+2σ) Cycloaddition of Bicyclo‐(1.1.0) butanes with Nitrones: Access to Polysubstituted 2‐Oxa‐3‐azabicyclo (3.1.1) heptanes
  Zhang, Jian ; Su, Jia‐Yi ; Zheng, Hanliang ; Li, Hao ; Deng, Wei‐Ping
• Efficient Synthesis of New 2‐Cycloalk (en) ylpropanoic Acid Derivatives—Medium and Large Rings as Bioisosteres of Alkylphenyl Moieties? † ‡
  Greve, Björn ; Imming, Peter ; Laufer, Stefan
• Indoloparacyclophanes: Synthesis and Dopamine Receptor Binding of a Novel Arylbioisostere
  Ortner, Birgit ; Waibel, Reiner ; Gmeiner, Peter
• Indoloparacyclophanes: Synthesis and Dopamine Receptor Binding of a Novel Arylbioisostere
  Ortner, Birgit ; Waibel, Reiner ; Gmeiner, Peter